TRIMETHOPRIM

Trimethoprim Adverse Events Reported to the FDA Over Time

How are Trimethoprim adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Trimethoprim, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Trimethoprim is flagged as the suspect drug causing the adverse event.

Most Common Trimethoprim Adverse Events Reported to the FDA

What are the most common Trimethoprim adverse events reported to the FDA?

Pyrexia	373 (2.36%)
Renal Failure Acute	250 (1.58%)
Drug Interaction	224 (1.42%)
Rash	208 (1.32%)
Nausea	188 (1.19%)
Vomiting	162 (1.03%)
Urinary Tract Infection	158 (1%)
Hyperkalaemia	154 (.98%)
Malaise	153 (.97%)
Pruritus	121 (.77%)
Abdominal Pain	120 (.76%)
	Show More
Hypotension	110 (.7%)
White Blood Cell Count Increased	110 (.7%)
Diarrhoea	105 (.67%)
Stevens-johnson Syndrome	102 (.65%)
Dyspnoea	99 (.63%)
Thrombocytopenia	98 (.62%)
Dizziness	97 (.61%)
Blood Creatinine Increased	96 (.61%)
Asthenia	95 (.6%)
Headache	95 (.6%)
International Normalised Ratio Incr...	93 (.59%)
Urticaria	93 (.59%)
Confusional State	92 (.58%)
Drug Hypersensitivity	91 (.58%)
Dehydration	88 (.56%)
Neutropenia	86 (.54%)
Pain	85 (.54%)
Chills	84 (.53%)
Renal Impairment	84 (.53%)
Pancytopenia	80 (.51%)
Staphylococcal Infection	80 (.51%)
Constipation	78 (.49%)
Haemoglobin Decreased	78 (.49%)
Rhabdomyolysis	75 (.48%)
Sepsis	75 (.48%)
Anaemia	73 (.46%)
Fatigue	72 (.46%)
Condition Aggravated	71 (.45%)
Hypertension	71 (.45%)
Sinus Tachycardia	68 (.43%)
Convulsion	67 (.42%)
Hypersensitivity	67 (.42%)
Diabetes Mellitus	66 (.42%)
Cardiac Murmur	64 (.41%)
Platelet Count Decreased	64 (.41%)
Toxic Epidermal Necrolysis	64 (.41%)
Skin Disorder	63 (.4%)
Pneumocystis Jiroveci Pneumonia	62 (.39%)
Abdominal Tenderness	61 (.39%)
Arthralgia	61 (.39%)
Drug Ineffective	61 (.39%)
Hiatus Hernia	60 (.38%)
Iron Deficiency Anaemia	60 (.38%)
Neutrophil Count Increased	60 (.38%)
Erythema	59 (.37%)
Decreased Appetite	58 (.37%)
Mean Cell Volume Decreased	58 (.37%)
Hyponatraemia	56 (.35%)
Tachycardia	56 (.35%)
Body Mass Index Decreased	55 (.35%)
Pneumonia	55 (.35%)
Rash Generalised	55 (.35%)
Tremor	55 (.35%)
General Physical Health Deteriorati...	54 (.34%)
Multi-organ Failure	54 (.34%)
Monocyte Count Increased	53 (.34%)
Blood Urea Increased	52 (.33%)
Leukopenia	52 (.33%)
Deep Vein Thrombosis	51 (.32%)
Angioedema	49 (.31%)
Chromaturia	49 (.31%)
Drug Rash With Eosinophilia And Sys...	48 (.3%)
Hypovolaemic Shock	46 (.29%)
Respiratory Failure	46 (.29%)
Drug Exposure During Pregnancy	44 (.28%)
Loss Of Consciousness	43 (.27%)
Pain In Extremity	43 (.27%)
Renal Failure	43 (.27%)
Bone Marrow Failure	42 (.27%)
Death	42 (.27%)
Rash Erythematous	42 (.27%)
Weight Decreased	42 (.27%)
Myalgia	41 (.26%)
Oedema Peripheral	41 (.26%)
Physical Assault	41 (.26%)
Retroperitoneal Haematoma	41 (.26%)
White Blood Cell Disorder	41 (.26%)
Tubulointerstitial Nephritis	40 (.25%)
Septic Shock	39 (.25%)
Alanine Aminotransferase Increased	38 (.24%)
Cough	38 (.24%)
Hepatitis	38 (.24%)
Hypoglycaemia	38 (.24%)
White Blood Cell Count Decreased	38 (.24%)
Abdominal Pain Upper	36 (.23%)
Jaundice	36 (.23%)
Lower Respiratory Tract Infection	36 (.23%)
Rash Maculo-papular	36 (.23%)
Ureteric Obstruction	36 (.23%)
Aspartate Aminotransferase Increase...	35 (.22%)

Share/Embed Graph Export Data

This graph shows the top adverse events submitted to the FDA for Trimethoprim, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Trimethoprim is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Trimethoprim

What are the most common Trimethoprim adverse events reported to the FDA?

Epidermal And Dermal Conditions	1264 (8.01%)
Infections - Pathogen Unspecified	683 (4.33%)
Hematology Investigations	677 (4.29%)
Gastrointestinal Signs	676 (4.28%)
Renal Disorders	446 (2.82%)
Neurological	444 (2.81%)
Respiratory	409 (2.59%)
Body Temperature Conditions	385 (2.44%)
Hepatic And Hepatobiliary	369 (2.34%)
Therapeutic And Nontherapeutic Effe...	357 (2.26%)
Electrolyte And Fluid Balance Condi...	339 (2.15%)
	Show More
Bacterial Infectious	296 (1.87%)
Anemias Nonhemolytic And Marrow Dep...	293 (1.86%)
White Blood Cell	283 (1.79%)
Cardiac Arrhythmias	261 (1.65%)
Muscle	249 (1.58%)
Gastrointestinal Motility And Defec...	210 (1.33%)
Allergic Conditions	209 (1.32%)
Renal And Urinary Tract Investigati...	205 (1.3%)
Hepatobiliary	192 (1.22%)
Cardiac And Vascular Investigations	186 (1.18%)
Viral Infectious	179 (1.13%)
Fungal Infectious	177 (1.12%)
Decreased And Nonspecific Blood Pre...	173 (1.1%)
Urinary Tract Signs	155 (.98%)
Angiedema And Urticaria	145 (.92%)
Physical Examination Topics	135 (.86%)
Musculoskeletal And Connective Tiss...	128 (.81%)
Deliria	126 (.8%)
Glucose Metabolism Disorders	124 (.79%)
Appetite And General Nutritional	119 (.75%)
Platelet	116 (.73%)
Movement Disorders	115 (.73%)
Ocular Infections, Irritations And ...	113 (.72%)
Oral Soft Tissue Conditions	106 (.67%)
Lower Respiratory Tract Disorders	104 (.66%)
Headaches	101 (.64%)
Chemical Injury And Poisoning	100 (.63%)
Seizures	97 (.61%)
Water, Electrolyte And Mineral	91 (.58%)
Injuries	90 (.57%)
Enzyme	86 (.54%)
Vascular Hypertensive	80 (.51%)
Nephropathies	79 (.5%)
Medication Errors	78 (.49%)
Joint	77 (.49%)
Peritoneal And Retroperitoneal Cond...	73 (.46%)
Procedural And Device Related Injur...	71 (.45%)
Anxiety Disorders	67 (.42%)
Abdominal Hernias And Other Abdomin...	60 (.38%)
Embolism And Thrombosis	60 (.38%)
Immune	60 (.38%)
Eye	59 (.37%)
Skin Vascular Abnormalities	59 (.37%)
Gastrointestinal Hemorrhages	58 (.37%)
Upper Respiratory Tract Disorders	57 (.36%)
Fatal Outcomes	54 (.34%)
Bronchial Disorders	53 (.34%)
Microbiology And Serology	52 (.33%)
Acid-base	49 (.31%)
Protein And Chemistry Analyses	48 (.3%)
Skin Appendage Conditions	47 (.3%)
Central Nervous System Vascular	45 (.29%)
Coagulopathies And Bleeding Diathes...	45 (.29%)
Spleen, Lymphatic And Reticulendoth...	45 (.29%)
Metabolic, Nutritional And Blood Ga...	44 (.28%)
Pleural	44 (.28%)
Ureteric	44 (.28%)
Vision	44 (.28%)
Heart Failures	43 (.27%)
Toxicology And Therapeutic Drug Mon...	42 (.27%)
Legal Issues	41 (.26%)
Psychiatric	41 (.26%)
Exocrine Pancreas Conditions	39 (.25%)
Neuromuscular	39 (.25%)
Suicidal And Self-injurious Behavio...	39 (.25%)
Vascular Hemorrhagic	39 (.25%)
Lifestyle Issues	38 (.24%)
Tongue Conditions	38 (.24%)
Sleep Disorders	37 (.23%)
Vascular	37 (.23%)
Depressed Mood Disorders	36 (.23%)
Encephalopathies	34 (.22%)
Neurological, Special Senses And Ps...	34 (.22%)
Cardiac Disorder Signs	33 (.21%)
Hematological And Lymphoid Tissue T...	33 (.21%)
Disturbances In Thinking	32 (.2%)
Mental Impairment	31 (.2%)
Metabolic And Nutritional Disorders...	31 (.2%)
Tissue	31 (.2%)
Administration Site Reactions	30 (.19%)
Hypothalamus And Pituitary Gland	30 (.19%)
Abortions And Stillbirth	29 (.18%)
Immunodeficiency Syndromes	27 (.17%)
Myocardial	27 (.17%)
Hemolyses And Related Conditions	26 (.16%)
Pregnancy, Labour, Delivery And Pos...	26 (.16%)
Lipid Metabolism	23 (.15%)
Cranial Nerve Disorders	22 (.14%)
Skin And Subcutaneous Tissue	22 (.14%)
Mycobacterial Infectious	21 (.13%)

Share/Embed Graph Export Data

This graph shows the top categories of adverse events submitted to the FDA for Trimethoprim, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Trimethoprim is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.