METOPROLOL

Metoprolol Adverse Events Reported to the FDA Over Time

How are Metoprolol adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Metoprolol, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Metoprolol is flagged as the suspect drug causing the adverse event.

Most Common Metoprolol Adverse Events Reported to the FDA

What are the most common Metoprolol adverse events reported to the FDA?

Dizziness	1135 (1.9%)
Hypotension	1006 (1.69%)
Bradycardia	951 (1.6%)
Hypertension	931 (1.56%)
Malaise	895 (1.5%)
Fatigue	868 (1.46%)
Drug Ineffective	781 (1.31%)
Dyspnoea	779 (1.31%)
Blood Pressure Increased	771 (1.29%)
Completed Suicide	702 (1.18%)
Headache	683 (1.15%)
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Nausea	643 (1.08%)
Drug Dose Omission	582 (.98%)
Syncope	578 (.97%)
Asthenia	535 (.9%)
Myocardial Infarction	528 (.89%)
Fall	485 (.81%)
Palpitations	476 (.8%)
Chest Pain	462 (.77%)
Drug Interaction	453 (.76%)
Heart Rate Increased	451 (.76%)
Cerebrovascular Accident	405 (.68%)
Diarrhoea	391 (.66%)
Atrial Fibrillation	372 (.62%)
Feeling Abnormal	363 (.61%)
Insomnia	359 (.6%)
Oedema Peripheral	339 (.57%)
Heart Rate Decreased	328 (.55%)
Anxiety	308 (.52%)
Somnolence	299 (.5%)
Vomiting	288 (.48%)
Cardiac Arrest	287 (.48%)
Cardiac Disorder	286 (.48%)
Weight Decreased	286 (.48%)
Confusional State	284 (.48%)
Cough	278 (.47%)
Loss Of Consciousness	270 (.45%)
Pain In Extremity	267 (.45%)
Medication Error	265 (.44%)
Depression	259 (.43%)
Blood Pressure Decreased	255 (.43%)
Death	254 (.43%)
Pain	253 (.42%)
Overdose	228 (.38%)
Diabetes Mellitus	223 (.37%)
Tachycardia	222 (.37%)
Alopecia	220 (.37%)
Hyperhidrosis	220 (.37%)
Blood Glucose Increased	212 (.36%)
Rash	210 (.35%)
Blood Pressure Inadequately Control...	206 (.35%)
Renal Failure Acute	206 (.35%)
Arthralgia	204 (.34%)
Pruritus	203 (.34%)
Heart Rate Irregular	200 (.34%)
Weight Increased	199 (.33%)
Cardiogenic Shock	198 (.33%)
Back Pain	193 (.32%)
Intentional Drug Misuse	187 (.31%)
Suicide Attempt	186 (.31%)
Gait Disturbance	184 (.31%)
Tremor	182 (.31%)
Muscle Spasms	181 (.3%)
Condition Aggravated	179 (.3%)
Vision Blurred	179 (.3%)
Off Label Use	178 (.3%)
Dehydration	176 (.3%)
Myalgia	175 (.29%)
Chest Discomfort	174 (.29%)
Abdominal Discomfort	171 (.29%)
Hypoaesthesia	171 (.29%)
Gastrooesophageal Reflux Disease	170 (.29%)
Intentional Overdose	170 (.29%)
Drug Hypersensitivity	166 (.28%)
Abdominal Pain	165 (.28%)
Arrhythmia	165 (.28%)
Renal Failure	158 (.27%)
Angina Pectoris	155 (.26%)
Incorrect Dose Administered	155 (.26%)
Hyperkalaemia	153 (.26%)
Sinus Bradycardia	151 (.25%)
Abdominal Pain Upper	148 (.25%)
Memory Impairment	147 (.25%)
Constipation	146 (.24%)
Wrong Technique In Drug Usage Proce...	145 (.24%)
Paraesthesia	144 (.24%)
Dry Mouth	141 (.24%)
Anaemia	136 (.23%)
Cardiac Failure Congestive	132 (.22%)
Hypersensitivity	131 (.22%)
Blood Cholesterol Increased	130 (.22%)
Dyspepsia	129 (.22%)
Convulsion	127 (.21%)
Hypoglycaemia	126 (.21%)
Nasopharyngitis	125 (.21%)
Neoplasm Malignant	125 (.21%)
Pneumonia	125 (.21%)
Product Substitution Issue	125 (.21%)
Bronchitis	124 (.21%)
Peripheral Coldness	124 (.21%)
Nightmare	123 (.21%)

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This graph shows the top adverse events submitted to the FDA for Metoprolol, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Metoprolol is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Metoprolol

What are the most common Metoprolol adverse events reported to the FDA?

Neurological	3810 (6.39%)
Cardiac Arrhythmias	3429 (5.75%)
Cardiac And Vascular Investigations	2787 (4.67%)
Medication Errors	2214 (3.71%)
Gastrointestinal Signs	1989 (3.34%)
Respiratory	1935 (3.25%)
Therapeutic And Nontherapeutic Effe...	1909 (3.2%)
Decreased And Nonspecific Blood Pre...	1584 (2.66%)
Epidermal And Dermal Conditions	1230 (2.06%)
Coronary Artery	1132 (1.9%)
Injuries	1045 (1.75%)
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Vascular Hypertensive	1029 (1.73%)
Suicidal And Self-injurious Behavio...	1001 (1.68%)
Infections - Pathogen Unspecified	917 (1.54%)
Cardiac Disorder Signs	863 (1.45%)
Headaches	785 (1.32%)
Musculoskeletal And Connective Tiss...	759 (1.27%)
Anxiety Disorders	758 (1.27%)
Gastrointestinal Motility And Defec...	757 (1.27%)
Sleep Disorders	754 (1.26%)
Central Nervous System Vascular	705 (1.18%)
Muscle	664 (1.11%)
Renal Disorders	655 (1.1%)
Physical Examination Topics	619 (1.04%)
Joint	594 (1%)
Electrolyte And Fluid Balance Condi...	589 (.99%)
Skin Appendage Conditions	581 (.97%)
Vision	539 (.9%)
Glucose Metabolism Disorders	525 (.88%)
Heart Failures	501 (.84%)
Metabolic, Nutritional And Blood Ga...	431 (.72%)
Hematology Investigations	416 (.7%)
Therapeutic Procedures And Supporti...	409 (.69%)
Deliria	399 (.67%)
Mental Impairment	388 (.65%)
Bone And Joint Injuries	379 (.64%)
Chemical Injury And Poisoning	379 (.64%)
Allergic Conditions	374 (.63%)
Movement Disorders	361 (.61%)
Psychiatric	356 (.6%)
Vascular	323 (.54%)
Fatal Outcomes	321 (.54%)
Bronchial Disorders	306 (.51%)
Renal And Urinary Tract Investigati...	305 (.51%)
Depressed Mood Disorders	300 (.5%)
Hepatobiliary	297 (.5%)
Arteriosclerosis, Stenosis, Vascula...	290 (.49%)
Product Quality Issues	286 (.48%)
Lifestyle Issues	284 (.48%)
Water, Electrolyte And Mineral	278 (.47%)
Hepatic And Hepatobiliary	275 (.46%)
Myocardial	275 (.46%)
Urinary Tract Signs	273 (.46%)
Lower Respiratory Tract Disorders	266 (.45%)
Appetite And General Nutritional	262 (.44%)
Lipid Analyses	253 (.42%)
Upper Respiratory Tract Disorders	231 (.39%)
Inner Ear And Viiith Cranial Nerve	199 (.33%)
Viral Infectious	184 (.31%)
Eye	183 (.31%)
Disturbances In Thinking	178 (.3%)
Anemias Nonhemolytic And Marrow Dep...	172 (.29%)
Cardiac Therapeutic Procedures	168 (.28%)
Miscellaneous And Site Unspecified ...	166 (.28%)
Acid-base	164 (.28%)
Seizures	161 (.27%)
Procedural And Device Related Injur...	158 (.27%)
Salivary Gland Conditions	151 (.25%)
Gastrointestinal Hemorrhages	147 (.25%)
Bacterial Infectious	140 (.23%)
Cardiac Valve	140 (.23%)
Vascular Hemorrhagic	133 (.22%)
Oral Soft Tissue Conditions	127 (.21%)
Mood Disorders	124 (.21%)
Ocular Infections, Irritations And ...	120 (.2%)
Tissue	119 (.2%)
Angiedema And Urticaria	118 (.2%)
Hearing	118 (.2%)
Embolism And Thrombosis	113 (.19%)
Pulmonary Vascular	110 (.18%)
Gastrointestinal Conditions	109 (.18%)
Body Temperature Conditions	107 (.18%)
Enzyme	107 (.18%)
Tongue Conditions	104 (.17%)
Peripheral Neuropathies	103 (.17%)
Vascular Therapeutic Procedures	103 (.17%)
Bone Disorders	93 (.16%)
Musculoskeletal And Connective Tiss...	93 (.16%)
Hematological And Lymphoid Tissue T...	91 (.15%)
Gastrointestinal Inflammatory Condi...	89 (.15%)
Toxicology And Therapeutic Drug Mon...	86 (.14%)
Psychiatric And Behavioural Symptom...	85 (.14%)
Gastrointestinal Neoplasms Malignan...	84 (.14%)
Bone And Joint Therapeutic Procedur...	83 (.14%)
Neonatal And Perinatal Conditions	82 (.14%)
Pleural	80 (.13%)
Lipid Metabolism	78 (.13%)
Ocular Structural Change, Deposit A...	78 (.13%)
Breast Neoplasms Malignant And Unsp...	75 (.13%)
Thyroid Gland	74 (.12%)
Gastrointestinal Ulceration And Per...	73 (.12%)

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This graph shows the top categories of adverse events submitted to the FDA for Metoprolol, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Metoprolol is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.