METHYLPREDNISOLONE

Methylprednisolone Adverse Events Reported to the FDA Over Time

How are Methylprednisolone adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Methylprednisolone, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Methylprednisolone is flagged as the suspect drug causing the adverse event.

Most Common Methylprednisolone Adverse Events Reported to the FDA

What are the most common Methylprednisolone adverse events reported to the FDA?

Pyrexia	498 (1.06%)
Dyspnoea	455 (.96%)
Drug Ineffective	387 (.82%)
Sepsis	346 (.73%)
Headache	338 (.72%)
Cytomegalovirus Infection	336 (.71%)
Nausea	313 (.66%)
Pneumonia	311 (.66%)
Respiratory Failure	299 (.63%)
Condition Aggravated	293 (.62%)
Thrombocytopenia	271 (.57%)
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Vomiting	266 (.56%)
Multi-organ Failure	264 (.56%)
Diarrhoea	253 (.54%)
Anaemia	250 (.53%)
Neutropenia	240 (.51%)
Hypertension	231 (.49%)
Asthenia	225 (.48%)
Renal Failure	219 (.46%)
Hypotension	212 (.45%)
Malaise	212 (.45%)
Pain	212 (.45%)
Abdominal Pain	203 (.43%)
Erythema	203 (.43%)
Osteonecrosis	198 (.42%)
Rash	198 (.42%)
Diabetes Mellitus	194 (.41%)
Hypersensitivity	184 (.39%)
Pruritus	184 (.39%)
Fatigue	177 (.38%)
Blood Pressure Increased	174 (.37%)
Convulsion	174 (.37%)
Arthralgia	167 (.35%)
Septic Shock	166 (.35%)
Back Pain	165 (.35%)
Urticaria	161 (.34%)
Interstitial Lung Disease	159 (.34%)
Dizziness	158 (.34%)
Depression	157 (.33%)
Renal Impairment	157 (.33%)
Tachycardia	157 (.33%)
Pain In Extremity	152 (.32%)
Anxiety	150 (.32%)
Transplant Rejection	150 (.32%)
Cardiac Arrest	146 (.31%)
Loss Of Consciousness	145 (.31%)
Multiple Sclerosis Relapse	143 (.3%)
Haemoglobin Decreased	140 (.3%)
Tendon Rupture	140 (.3%)
Hyperglycaemia	139 (.29%)
Anaphylactic Shock	134 (.28%)
Chest Pain	134 (.28%)
Hypoaesthesia	134 (.28%)
Pleural Effusion	134 (.28%)
Aspergillosis	133 (.28%)
General Physical Health Deteriorati...	133 (.28%)
Blood Glucose Increased	132 (.28%)
Acute Respiratory Distress Syndrome	130 (.28%)
Infection	130 (.28%)
Renal Failure Acute	130 (.28%)
Confusional State	129 (.27%)
Weight Increased	129 (.27%)
Atrial Fibrillation	128 (.27%)
Drug Interaction	128 (.27%)
Platelet Count Decreased	128 (.27%)
Oedema Peripheral	127 (.27%)
Kidney Transplant Rejection	125 (.27%)
Staphylococcal Infection	124 (.26%)
Paraesthesia	123 (.26%)
Respiratory Distress	123 (.26%)
Hepatic Function Abnormal	122 (.26%)
Tremor	122 (.26%)
Anaphylactic Reaction	121 (.26%)
Blood Pressure Decreased	121 (.26%)
Gastrointestinal Haemorrhage	121 (.26%)
Pneumocystis Jiroveci Pneumonia	121 (.26%)
Aspartate Aminotransferase Increase...	120 (.25%)
Blood Creatinine Increased	120 (.25%)
Weight Decreased	120 (.25%)
Chills	118 (.25%)
Hyperhidrosis	117 (.25%)
Muscular Weakness	116 (.25%)
Pancytopenia	114 (.24%)
Alanine Aminotransferase Increased	112 (.24%)
Insomnia	112 (.24%)
Urinary Tract Infection	112 (.24%)
Fall	111 (.24%)
Tendonitis	110 (.23%)
Death	108 (.23%)
Flushing	108 (.23%)
Drug Exposure During Pregnancy	107 (.23%)
Haemodialysis	106 (.22%)
Shock	106 (.22%)
Oxygen Saturation Decreased	105 (.22%)
Psychotic Disorder	105 (.22%)
Bradycardia	104 (.22%)
Disseminated Intravascular Coagulat...	104 (.22%)
Leukopenia	104 (.22%)
Heart Rate Increased	101 (.21%)
Peritonitis	101 (.21%)
Rotator Cuff Syndrome	100 (.21%)

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This graph shows the top adverse events submitted to the FDA for Methylprednisolone, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Methylprednisolone is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Methylprednisolone

What are the most common Methylprednisolone adverse events reported to the FDA?

Infections - Pathogen Unspecified	2330 (4.94%)
Respiratory	1675 (3.55%)
Neurological	1631 (3.46%)
Epidermal And Dermal Conditions	1420 (3.01%)
Gastrointestinal Signs	1196 (2.54%)
Viral Infectious	1081 (2.29%)
Bacterial Infectious	1055 (2.24%)
Hepatic And Hepatobiliary	1011 (2.14%)
Cardiac Arrhythmias	860 (1.82%)
Hematology Investigations	816 (1.73%)
Fungal Infectious	808 (1.71%)
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Renal Disorders	800 (1.7%)
Therapeutic And Nontherapeutic Effe...	714 (1.51%)
Lower Respiratory Tract Disorders	668 (1.42%)
White Blood Cell	601 (1.27%)
Cardiac And Vascular Investigations	594 (1.26%)
Allergic Conditions	592 (1.26%)
Injuries	583 (1.24%)
Body Temperature Conditions	575 (1.22%)
Immune	545 (1.16%)
Anemias Nonhemolytic And Marrow Dep...	523 (1.11%)
Procedural And Device Related Injur...	518 (1.1%)
Hepatobiliary	514 (1.09%)
Joint	495 (1.05%)
Musculoskeletal And Connective Tiss...	485 (1.03%)
Muscle	455 (.96%)
Movement Disorders	425 (.9%)
Decreased And Nonspecific Blood Pre...	424 (.9%)
Electrolyte And Fluid Balance Condi...	413 (.88%)
Gastrointestinal Motility And Defec...	411 (.87%)
Glucose Metabolism Disorders	407 (.86%)
Central Nervous System Vascular	384 (.81%)
Headaches	380 (.81%)
Administration Site Reactions	379 (.8%)
Bone Disorders	352 (.75%)
Physical Examination Topics	336 (.71%)
Medication Errors	334 (.71%)
Platelet	330 (.7%)
Metabolic, Nutritional And Blood Ga...	322 (.68%)
Anxiety Disorders	308 (.65%)
Seizures	307 (.65%)
Vision	290 (.61%)
Urinary Tract Signs	287 (.61%)
Gastrointestinal Ulceration And Per...	284 (.6%)
Gastrointestinal Hemorrhages	283 (.6%)
Vascular	282 (.6%)
Bronchial Disorders	271 (.57%)
Skin Appendage Conditions	268 (.57%)
Demyelinating	256 (.54%)
Peritoneal And Retroperitoneal Cond...	256 (.54%)
Vascular Hypertensive	247 (.52%)
Renal And Urinary Tract Investigati...	242 (.51%)
Deliria	241 (.51%)
Pleural	239 (.51%)
Coronary Artery	238 (.5%)
Encephalopathies	237 (.5%)
Angiedema And Urticaria	221 (.47%)
Tendon, Ligament And Cartilage	218 (.46%)
Coagulopathies And Bleeding Diathes...	215 (.46%)
Microbiology And Serology	215 (.46%)
Hematological And Lymphoid Tissue T...	203 (.43%)
Nephropathies	201 (.43%)
Cardiac Disorder Signs	200 (.42%)
Chemical Injury And Poisoning	197 (.42%)
Enzyme	197 (.42%)
Depressed Mood Disorders	193 (.41%)
Gastrointestinal Inflammatory Condi...	187 (.4%)
Appetite And General Nutritional	186 (.39%)
Bone And Joint Injuries	176 (.37%)
Exocrine Pancreas Conditions	170 (.36%)
Embolism And Thrombosis	166 (.35%)
Hematopoietic Neoplasms	164 (.35%)
Disturbances In Thinking	161 (.34%)
Heart Failures	161 (.34%)
Sleep Disorders	161 (.34%)
Upper Respiratory Tract Disorders	156 (.33%)
Oral Soft Tissue Conditions	153 (.32%)
Mental Impairment	145 (.31%)
Vascular Hemorrhagic	145 (.31%)
Water, Electrolyte And Mineral	144 (.31%)
Fatal Outcomes	140 (.3%)
Tissue	138 (.29%)
Ocular Infections, Irritations And ...	134 (.28%)
Skin Vascular Abnormalities	132 (.28%)
Therapeutic Procedures And Supporti...	131 (.28%)
Lifestyle Issues	125 (.27%)
Peripheral Neuropathies	123 (.26%)
Myocardial	121 (.26%)
Ocular Neuromuscular	120 (.25%)
Protein And Chemistry Analyses	120 (.25%)
Skin And Subcutaneous Tissue	120 (.25%)
Mycobacterial Infectious	119 (.25%)
Schizophrenia And Other Psychotic	119 (.25%)
Hemolyses And Related Conditions	115 (.24%)
Mood Disorders	109 (.23%)
Immunodeficiency Syndromes	106 (.22%)
Adrenal Gland	102 (.22%)
Immunology And Allergy	101 (.21%)
Gastrointestinal Conditions	100 (.21%)
Cranial Nerve Disorders	99 (.21%)
Miscellaneous And Site Unspecified ...	99 (.21%)

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This graph shows the top categories of adverse events submitted to the FDA for Methylprednisolone, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Methylprednisolone is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.