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ENDOXAN

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Endoxan Adverse Events Reported to the FDA Over Time

How are Endoxan adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Endoxan, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Endoxan is flagged as the suspect drug causing the adverse event.

Most Common Endoxan Adverse Events Reported to the FDA

What are the most common Endoxan adverse events reported to the FDA?

Pyrexia
191 (2.19%)
Interstitial Lung Disease
141 (1.62%)
Febrile Neutropenia
116 (1.33%)
Pancytopenia
105 (1.21%)
Neutropenia
102 (1.17%)
Anaemia
100 (1.15%)
Sepsis
96 (1.1%)
Bone Marrow Failure
85 (.98%)
Acute Myeloid Leukaemia
80 (.92%)
Pneumonia
80 (.92%)
Thrombocytopenia
79 (.91%)
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White Blood Cell Count Decreased
77 (.88%)
Cardiac Failure
74 (.85%)
Stomatitis
72 (.83%)
Dyspnoea
71 (.82%)
Diarrhoea
69 (.79%)
Septic Shock
69 (.79%)
Renal Failure
66 (.76%)
Febrile Bone Marrow Aplasia
65 (.75%)
Vomiting
65 (.75%)
Platelet Count Decreased
61 (.7%)
Neutrophil Count Decreased
56 (.64%)
Cough
55 (.63%)
Lung Disorder
55 (.63%)
Agranulocytosis
53 (.61%)
Headache
53 (.61%)
Asthenia
50 (.57%)
Nausea
50 (.57%)
Chills
49 (.56%)
Respiratory Failure
49 (.56%)
Condition Aggravated
45 (.52%)
Death
44 (.51%)
Pleural Effusion
44 (.51%)
Alanine Aminotransferase Increased
43 (.49%)
Cytolytic Hepatitis
43 (.49%)
Convulsion
42 (.48%)
Renal Failure Acute
42 (.48%)
Multi-organ Failure
39 (.45%)
Hyponatraemia
37 (.43%)
Leukopenia
36 (.41%)
Treatment Related Secondary Maligna...
36 (.41%)
Coma
34 (.39%)
Hepatic Function Abnormal
34 (.39%)
Hyperpyrexia
34 (.39%)
Renal Impairment
34 (.39%)
Confusional State
33 (.38%)
Liver Disorder
33 (.38%)
Mucosal Inflammation
33 (.38%)
Acute Respiratory Distress Syndrome
32 (.37%)
Hypokalaemia
32 (.37%)
Malignant Neoplasm Progression
32 (.37%)
Atrial Fibrillation
30 (.34%)
Haemoglobin Decreased
30 (.34%)
Malaise
30 (.34%)
Gamma-glutamyltransferase Increased
29 (.33%)
Herpes Zoster
29 (.33%)
Myelodysplastic Syndrome
29 (.33%)
Pulmonary Embolism
29 (.33%)
Rash
29 (.33%)
Respiratory Distress
29 (.33%)
Stevens-johnson Syndrome
29 (.33%)
Dehydration
28 (.32%)
Hypotension
28 (.32%)
Infection
28 (.32%)
Progressive Multifocal Leukoencepha...
28 (.32%)
Pulmonary Fibrosis
28 (.32%)
Encephalopathy
26 (.3%)
Hypertension
26 (.3%)
Blood Alkaline Phosphatase Increase...
25 (.29%)
Aspartate Aminotransferase Increase...
24 (.28%)
Cerebral Haemorrhage
24 (.28%)
Cholestasis
24 (.28%)
Cytomegalovirus Infection
23 (.26%)
Hepatitis
23 (.26%)
Tumour Lysis Syndrome
23 (.26%)
Aplasia
22 (.25%)
Back Pain
22 (.25%)
Erythema
22 (.25%)
Osteonecrosis
22 (.25%)
Pneumocystis Jiroveci Pneumonia
22 (.25%)
Pulmonary Oedema
22 (.25%)
Shock
22 (.25%)
Venoocclusive Liver Disease
22 (.25%)
Cardiac Arrest
21 (.24%)
Cystitis Haemorrhagic
21 (.24%)
Hepatic Failure
21 (.24%)
Hepatitis B
21 (.24%)
Acute Pulmonary Oedema
20 (.23%)
Blood Lactate Dehydrogenase Increas...
20 (.23%)
Blood Pressure Decreased
20 (.23%)
Encephalitis
20 (.23%)
Gastrointestinal Haemorrhage
20 (.23%)
Tachycardia
20 (.23%)
Altered State Of Consciousness
19 (.22%)
Bone Sarcoma
19 (.22%)
C-reactive Protein Increased
19 (.22%)
Deep Vein Thrombosis
19 (.22%)
Disseminated Intravascular Coagulat...
19 (.22%)
Inappropriate Antidiuretic Hormone ...
19 (.22%)
Neuropathy Peripheral
19 (.22%)
Oedema
19 (.22%)

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This graph shows the top adverse events submitted to the FDA for Endoxan, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Endoxan is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Endoxan

What are the most common Endoxan adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Endoxan, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Endoxan is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Endoxan According to Those Reporting Adverse Events

Why are people taking Endoxan, according to those reporting adverse events to the FDA?

Breast Cancer
491
Non-hodgkins Lymphoma
194
Lymphoma
169
Drug Use For Unknown Indication
137
Chronic Lymphocytic Leukaemia
129
Acute Lymphocytic Leukaemia
107
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Diffuse Large B-cell Lymphoma
84
B-cell Lymphoma
82
Multiple Myeloma
76
Systemic Lupus Erythematosus
57
Stem Cell Transplant
46
Bone Marrow Conditioning Regimen
41
Breast Cancer Metastatic
34
Rheumatoid Arthritis
32
Chemotherapy
32
Wegeners Granulomatosis
32
Product Used For Unknown Indication
31
Burkitts Lymphoma
31
Bone Marrow Transplant
28
Hodgkins Disease
27
Mantle Cell Lymphoma
26
Neoplasm Malignant
26
Off Label Use
25
Multiple Sclerosis
25
Rhabdomyosarcoma
24
Ovarian Cancer
21
Metastases To Bone
18
Adult T-cell Lymphoma/leukaemia
17
Interstitial Lung Disease
17
Breast Cancer Recurrent
16
Lupus Nephritis
15
Neuroblastoma
15
Acute Myeloid Leukaemia
14
Glomerulonephritis
14
Breast Cancer Female
13
Chronic Myeloid Leukaemia
13
Vasculitis
12
Primary Mediastinal Large B-cell Ly...
12
Waldenstroms Macroglobulinaemia
11
Bone Sarcoma
11
Lymphocytic Leukaemia
11
Dermatomyositis
11
Microscopic Polyangiitis
11
Acquired Haemophilia
11
Non-hodgkins Lymphoma Stage Iv
10
Peripheral T-cell Lymphoma Unspecif...
9
T-cell Lymphoma
9
B-cell Small Lymphocytic Lymphoma
9
T-cell Prolymphocytic Leukaemia
8
Prostate Cancer
8
Sjogrens Syndrome
8

Endoxan Case Reports

What Endoxan safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Endoxan. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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