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PEMETREXED DISODIUM

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Pemetrexed Disodium Adverse Events Reported to the FDA Over Time

How are Pemetrexed Disodium adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Pemetrexed Disodium, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Pemetrexed Disodium is flagged as the suspect drug causing the adverse event.

Most Common Pemetrexed Disodium Adverse Events Reported to the FDA

What are the most common Pemetrexed Disodium adverse events reported to the FDA?

Anaemia
80 (3.23%)
Dehydration
64 (2.59%)
Thrombocytopenia
63 (2.55%)
Dyspnoea
57 (2.3%)
Nausea
50 (2.02%)
Pneumonia
41 (1.66%)
Diarrhoea
37 (1.5%)
Respiratory Failure
37 (1.5%)
Sepsis
37 (1.5%)
Febrile Neutropenia
34 (1.37%)
Fatigue
33 (1.33%)
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Neutropenia
33 (1.33%)
Syncope
33 (1.33%)
Abdominal Pain
32 (1.29%)
Vomiting
31 (1.25%)
Atrial Fibrillation
30 (1.21%)
Large Intestine Perforation
30 (1.21%)
Platelet Count Decreased
29 (1.17%)
Hypotension
27 (1.09%)
Death
25 (1.01%)
Decreased Appetite
25 (1.01%)
Malignant Neoplasm Progression
25 (1.01%)
Pleural Effusion
24 (.97%)
Lung Cancer Metastatic
23 (.93%)
Peritonitis
23 (.93%)
Constipation
21 (.85%)
General Physical Health Deteriorati...
21 (.85%)
Haemoglobin Decreased
21 (.85%)
Leukopenia
21 (.85%)
Asthenia
20 (.81%)
Neutrophil Count Decreased
20 (.81%)
Pancytopenia
20 (.81%)
Renal Failure
20 (.81%)
Confusional State
19 (.77%)
Hyponatraemia
19 (.77%)
Neoplasm Malignant
19 (.77%)
Renal Failure Acute
19 (.77%)
Pneumonia Aspiration
18 (.73%)
Haemoptysis
17 (.69%)
Dysphagia
16 (.65%)
Epistaxis
16 (.65%)
Blood Creatinine Increased
15 (.61%)
Chest Pain
15 (.61%)
Pyrexia
15 (.61%)
Hypokalaemia
14 (.57%)
Oesophagitis
14 (.57%)
Cerebrovascular Accident
13 (.53%)
Pneumonitis
13 (.53%)
Pulmonary Embolism
13 (.53%)
Vertigo
13 (.53%)
Hyperkalaemia
12 (.49%)
Mucosal Inflammation
12 (.49%)
Convulsion
11 (.44%)
Infection
11 (.44%)
Mental Status Changes
11 (.44%)
Weight Decreased
11 (.44%)
Cardiac Failure
10 (.4%)
Deep Vein Thrombosis
10 (.4%)
Hyperglycaemia
10 (.4%)
Pericardial Effusion
10 (.4%)
Coma
9 (.36%)
Disease Progression
9 (.36%)
Dizziness
9 (.36%)
Hearing Impaired
9 (.36%)
Hypoalbuminaemia
9 (.36%)
Shock
9 (.36%)
Tachycardia
9 (.36%)
Aspiration
8 (.32%)
Atrial Flutter
8 (.32%)
Blood Bilirubin Increased
8 (.32%)
Hypertension
8 (.32%)
White Blood Cell Count Decreased
8 (.32%)
Acute Respiratory Failure
7 (.28%)
Aspartate Aminotransferase Increase...
7 (.28%)
Atelectasis
7 (.28%)
Cerebral Infarction
7 (.28%)
Diverticulitis
7 (.28%)
Drug Toxicity
7 (.28%)
Fall
7 (.28%)
Hypocalcaemia
7 (.28%)
Hypophosphataemia
7 (.28%)
Hypothermia
7 (.28%)
Hypovolaemic Shock
7 (.28%)
Intra-abdominal Haemorrhage
7 (.28%)
Performance Status Decreased
7 (.28%)
Renal Impairment
7 (.28%)
Septic Shock
7 (.28%)
Supraventricular Tachycardia
7 (.28%)
C-reactive Protein Increased
6 (.24%)
Cardiac Arrest
6 (.24%)
Cardio-respiratory Arrest
6 (.24%)
Depression
6 (.24%)
Duodenal Ulcer
6 (.24%)
Haematocrit Decreased
6 (.24%)
Ileus Paralytic
6 (.24%)
Lung Infection
6 (.24%)
Malnutrition
6 (.24%)
Metastases To Liver
6 (.24%)
Metastases To Spleen
6 (.24%)
Microangiopathic Haemolytic Anaemia
6 (.24%)
Peridiverticular Abscess
6 (.24%)

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This graph shows the top adverse events submitted to the FDA for Pemetrexed Disodium, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Pemetrexed Disodium is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Pemetrexed Disodium

What are the most common Pemetrexed Disodium adverse events reported to the FDA?

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This graph shows the top categories of adverse events submitted to the FDA for Pemetrexed Disodium, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Pemetrexed Disodium is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Common Uses of Pemetrexed Disodium According to Those Reporting Adverse Events

Why are people taking Pemetrexed Disodium, according to those reporting adverse events to the FDA?

Non-small Cell Lung Cancer
391
Head And Neck Cancer
94
Mesothelioma
47
Lung Neoplasm Malignant
26
Non-small Cell Lung Cancer Stage Ii...
23
Non-small Cell Lung Cancer Metastat...
20
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Lung Adenocarcinoma Metastatic
13
Pleural Mesothelioma Malignant
13
Non-small Cell Lung Cancer Stage Iv
10
Small Cell Lung Cancer Stage Unspec...
9
Pleural Mesothelioma
8
Product Used For Unknown Indication
8
Bronchial Carcinoma
8
Breast Cancer
8
Lung Adenocarcinoma
7
Small Cell Lung Cancer Extensive St...
6
Adenocarcinoma
6
Neoplasm Malignant
4
Lung Cancer Metastatic
3
Hypopharyngeal Cancer
3
Oropharyngeal Cancer Stage Unspecif...
2
Metastatic Bronchial Carcinoma
2
Metastases To Bone
2
Squamous Cell Carcinoma
2
Metastases To Central Nervous Syste...
1
Peritoneal Mesothelioma Malignant
1
Mesothelioma Malignant
1
Peritoneal Neoplasm
1
Ovarian Cancer
1
Large Cell Carcinoma Of The Respira...
1
Non-small Cell Lung Cancer Recurren...
1
Malignant Peritoneal Neoplasm
1
Oesophageal Carcinoma
1
Lung Carcinoma Cell Type Unspecifie...
1
Lung Carcinoma Cell Type Unspecifie...
1
Fallopian Tube Cancer
1
Chemotherapy
1
Pericardial Mesothelioma Malignant ...
1
Ovarian Epithelial Cancer
1

Pemetrexed Disodium Case Reports

What Pemetrexed Disodium safety concerns are being reported by doctors and researchers in the medical literature?

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About Results

This report contains aggregated drug side effects and adverse events for Pemetrexed Disodium. The data has been pulled from the United States Food and Drug Administration's (US FDA) Adverse Event Reporting System (AERS), a database containing more than 4,000,000 adverse event reports.

DrugCite expands your query using the Unified Medical Language System (UMLS) to include generic drugs and primary active ingredients. While the core of DrugCite's advanced drug filtering algorithm is based on the industry standard UMLS, DrugCite's proprietary filtering system also includes dozens of additional steps to reconcile malformed drug names in the FDA's data.

DrugCite only counts a drug if the submitter of the adverse event indicates that the drug is suspected to have caused the adverse event.

Depending on how the data is aggregated, different counts may occur. When someone submits an adverse event to the FDA, the submitter can attribute multiple adverse events to one or more drugs. For example, an individual taking Paxil could submit the adverse events "anxiety" and "suicidal ideation" for the same individual safety report (ISR). This means when DrugCite aggregates by adverse event, two distinct adverse events are counted in the adverse event graph; once for "anxiety" and again for "suicidal ideation". However, when DrugCite aggregates by individual safety reports irrespective of the details of the adverse events contained within the safety report, the report is only counted once.

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