DOXYCYCLINE HYCLATE

Doxycycline Hyclate Adverse Events Reported to the FDA Over Time

How are Doxycycline Hyclate adverse event reports trending over time?

This graph shows volume of adverse events submitted to the FDA by quarter for Doxycycline Hyclate, as well as related generic and/or brandname drugs containing the same primary active ingredients. Adverse events are counted if Doxycycline Hyclate is flagged as the suspect drug causing the adverse event.

Most Common Doxycycline Hyclate Adverse Events Reported to the FDA

What are the most common Doxycycline Hyclate adverse events reported to the FDA?

Nausea	60 (1.86%)
Vomiting	58 (1.79%)
Drug Hypersensitivity	53 (1.64%)
Dyspnoea	46 (1.42%)
Drug Ineffective	42 (1.3%)
Diarrhoea	39 (1.21%)
Rash	39 (1.21%)
Chest Pain	37 (1.14%)
Headache	36 (1.11%)
Oesophageal Ulcer	36 (1.11%)
Dizziness	35 (1.08%)
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Drug Interaction	35 (1.08%)
Dysphagia	30 (.93%)
Hypersensitivity	30 (.93%)
Malaise	30 (.93%)
Arthralgia	28 (.87%)
Asthenia	27 (.84%)
Pain	27 (.84%)
Depression	26 (.8%)
Abdominal Discomfort	25 (.77%)
Stevens-johnson Syndrome	25 (.77%)
Paraesthesia	23 (.71%)
Pruritus	23 (.71%)
Erythema	22 (.68%)
Fatigue	22 (.68%)
Liver Function Test Abnormal	21 (.65%)
Abdominal Pain Upper	19 (.59%)
Blister	18 (.56%)
Urticaria	18 (.56%)
Weight Decreased	18 (.56%)
Burning Sensation	17 (.53%)
Confusional State	16 (.49%)
Gastrooesophageal Reflux Disease	16 (.49%)
Hypoaesthesia	16 (.49%)
Oropharyngeal Pain	16 (.49%)
Pyrexia	16 (.49%)
Aspartate Aminotransferase Increase...	15 (.46%)
Oedema Peripheral	15 (.46%)
Oesophagitis	15 (.46%)
Condition Aggravated	14 (.43%)
Drug Rash With Eosinophilia And Sys...	14 (.43%)
Dyspepsia	14 (.43%)
Feeling Abnormal	14 (.43%)
Alanine Aminotransferase Increased	13 (.4%)
Anxiety	13 (.4%)
Convulsion	13 (.4%)
Drug Exposure During Pregnancy	13 (.4%)
Photosensitivity Reaction	13 (.4%)
Abdominal Pain	12 (.37%)
Vision Blurred	12 (.37%)
Benign Intracranial Hypertension	11 (.34%)
Death	11 (.34%)
Hyperhidrosis	11 (.34%)
Hypoglycaemia	11 (.34%)
Muscle Spasms	11 (.34%)
Myocardial Infarction	11 (.34%)
Burn Oesophageal	10 (.31%)
Candidiasis	10 (.31%)
Disorientation	10 (.31%)
Fall	10 (.31%)
Feeling Hot	10 (.31%)
Interstitial Lung Disease	10 (.31%)
Nasopharyngitis	10 (.31%)
Palpitations	10 (.31%)
Pancreatitis	10 (.31%)
Renal Impairment	10 (.31%)
Somnolence	10 (.31%)
Abasia	9 (.28%)
Agitation	9 (.28%)
Amnesia	9 (.28%)
Dehydration	9 (.28%)
Gamma-glutamyltransferase Increased	9 (.28%)
Haematochezia	9 (.28%)
Hyperglycaemia	9 (.28%)
Myalgia	9 (.28%)
Visual Impairment	9 (.28%)
Abdominal Distension	8 (.25%)
Angioedema	8 (.25%)
Aphasia	8 (.25%)
Autoimmune Hepatitis	8 (.25%)
Blood Glucose Increased	8 (.25%)
Chest Discomfort	8 (.25%)
Constipation	8 (.25%)
Discomfort	8 (.25%)
Fungal Infection	8 (.25%)
Gait Disturbance	8 (.25%)
Hepatic Fibrosis	8 (.25%)
Hepatitis	8 (.25%)
Hepatitis Cholestatic	8 (.25%)
Insomnia	8 (.25%)
Liver Disorder	8 (.25%)
Mobility Decreased	8 (.25%)
Oesophageal Pain	8 (.25%)
Skin Burning Sensation	8 (.25%)
Swelling Face	8 (.25%)
Tinnitus	8 (.25%)
Blood Alkaline Phosphatase Increase...	7 (.22%)
Blood Pressure Fluctuation	7 (.22%)
Brucellosis	7 (.22%)
Chills	7 (.22%)
Cholestasis	7 (.22%)

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This graph shows the top adverse events submitted to the FDA for Doxycycline Hyclate, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Doxycycline Hyclate is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.

Adverse Event Categories for Doxycycline Hyclate

What are the most common Doxycycline Hyclate adverse events reported to the FDA?

Epidermal And Dermal Conditions	251 (7.76%)
Gastrointestinal Signs	249 (7.7%)
Neurological	179 (5.54%)
Respiratory	107 (3.31%)
Therapeutic And Nontherapeutic Effe...	92 (2.85%)
Allergic Conditions	89 (2.75%)
Hepatic And Hepatobiliary	80 (2.47%)
Gastrointestinal Motility And Defec...	71 (2.2%)
Hepatobiliary	69 (2.13%)
Infections - Pathogen Unspecified	63 (1.95%)
Gastrointestinal Ulceration And Per...	49 (1.52%)
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Muscle	45 (1.39%)
Anxiety Disorders	41 (1.27%)
Joint	40 (1.24%)
Bacterial Infectious	39 (1.21%)
Headaches	39 (1.21%)
Hematology Investigations	38 (1.18%)
Depressed Mood Disorders	34 (1.05%)
Fungal Infectious	34 (1.05%)
Musculoskeletal And Connective Tiss...	31 (.96%)
Oral Soft Tissue Conditions	31 (.96%)
Skin Appendage Conditions	30 (.93%)
Vision	30 (.93%)
Cardiac Arrhythmias	29 (.9%)
Physical Examination Topics	29 (.9%)
Renal Disorders	28 (.87%)
Angiedema And Urticaria	27 (.84%)
Gastrointestinal Inflammatory Condi...	27 (.84%)
Injuries	27 (.84%)
Deliria	26 (.8%)
Medication Errors	26 (.8%)
Glucose Metabolism Disorders	23 (.71%)
Lower Respiratory Tract Disorders	23 (.71%)
Mental Impairment	23 (.71%)
Urinary Tract Signs	22 (.68%)
Lifestyle Issues	21 (.65%)
Sleep Disorders	20 (.62%)
White Blood Cell	20 (.62%)
Chemical Injury And Poisoning	18 (.56%)
Seizures	18 (.56%)
Decreased And Nonspecific Blood Pre...	17 (.53%)
Suicidal And Self-injurious Behavio...	17 (.53%)
Body Temperature Conditions	16 (.49%)
Cardiac Disorder Signs	16 (.49%)
Gastrointestinal Conditions	16 (.49%)
Movement Disorders	16 (.49%)
Appetite And General Nutritional	15 (.46%)
Coronary Artery	15 (.46%)
Exocrine Pancreas Conditions	15 (.46%)
Gastrointestinal Hemorrhages	15 (.46%)
Injuries By Physical Agents	15 (.46%)
Mood Disorders	15 (.46%)
Vascular	15 (.46%)
Cardiac And Vascular Investigations	14 (.43%)
Disturbances In Thinking	14 (.43%)
Eye	14 (.43%)
Increased Intracranial Pressure And...	14 (.43%)
Inner Ear And Viiith Cranial Nerve	13 (.4%)
Fatal Outcomes	12 (.37%)
Metabolic, Nutritional And Blood Ga...	12 (.37%)
Peripheral Neuropathies	12 (.37%)
Sexual Function And Fertility	12 (.37%)
Lipid Analyses	11 (.34%)
Tongue Conditions	11 (.34%)
Anal And Rectal Conditions	10 (.31%)
Dental And Gingival Conditions	10 (.31%)
Electrolyte And Fluid Balance Condi...	10 (.31%)
Enzyme	10 (.31%)
Microbiology And Serology	10 (.31%)
Ocular Infections, Irritations And ...	10 (.31%)
Product Quality Issues	10 (.31%)
Renal And Urinary Tract Investigati...	10 (.31%)
Tissue	10 (.31%)
Bronchial Disorders	9 (.28%)
Changes In Physical Activity	9 (.28%)
Administration Site Reactions	8 (.25%)
Anemias Nonhemolytic And Marrow Dep...	8 (.25%)
Hemolyses And Related Conditions	8 (.25%)
Immune	8 (.25%)
Vascular Hemorrhagic	8 (.25%)
Central Nervous System Vascular	7 (.22%)
Coagulopathies And Bleeding Diathes...	7 (.22%)
Gallbladder	7 (.22%)
Platelet	7 (.22%)
Reproductive Tract	7 (.22%)
Spleen, Lymphatic And Reticulendoth...	7 (.22%)
Toxicology And Therapeutic Drug Mon...	7 (.22%)
Bone Disorders	6 (.19%)
Embolism And Thrombosis	6 (.19%)
Encephalopathies	6 (.19%)
Pericardial	6 (.19%)
Skin Vascular Abnormalities	6 (.19%)
Therapeutic Procedures And Supporti...	6 (.19%)
Abortions And Stillbirth	5 (.15%)
Arteriosclerosis, Stenosis, Vascula...	5 (.15%)
Cranial Nerve Disorders	5 (.15%)
Psychiatric And Behavioural Symptom...	5 (.15%)
Salivary Gland Conditions	5 (.15%)
Sexual Dysfunctions, Disturbances A...	5 (.15%)
Upper Respiratory Tract Disorders	5 (.15%)
Bone And Joint Injuries	4 (.12%)

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This graph shows the top categories of adverse events submitted to the FDA for Doxycycline Hyclate, as well as related generic and/or brandname drugs containing the same primary active ingredients, from Q1 2004 to Q3 2012. Adverse events are counted if Doxycycline Hyclate is flagged as a suspect drug causing the adverse event. For each adverse event listed, percent (%) represents percentage of the adverse event to all adverse events reported for the drug. Percent does not represent a rate related to drug utilization.